Matches in Nanopublications for { <https://w3id.org/ro-id/9641a891-0c97-4a21-bcc5-3c0e7f974ede/> ?p ?o ?g. }
Showing items 1 to 21 of
21
with 100 items per page.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede type BibliographyResearchObject assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede type BibliographyResearchObject assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede type ResearchObject assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede type LiveRO assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede type Dataset assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede description "Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous system caused by the random inactivation of the X-chromosome, in the case of X-linked pathologies, or by somatic mutations affecting a subset of neurons. The comprehension of the mechanisms of these diseases and of the cell-autonomous effects of specific mutations requires the generation of sparse mosaic models, in which the genotype of each neuron is univocally identified by the expression of a fluorescent protein in vivo. Here, we show a dual-color reporter system that, when expressed in a floxed mouse line for a target gene, leads to the creation of mosaics with tunable degree. We demonstrate the generation of a knockout mosaic of the autism/epilepsy related gene PTEN in which the genotype of each neuron is reliably identified, and the neuronal phenotype is accurately characterized by two-photon microscopy." assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede contentSize "5271" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede dateCreated "2021-12-10 10:05:58.607206+00:00" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede creation_mode "MANUAL" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede cite-as "Foglini, Federica. "Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter." ROHub. Dec 10 ,2021. https://w3id.org/ro-id/9641a891-0c97-4a21-bcc5-3c0e7f974ede." assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede about 4921 assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede name "Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede contentUrl "https://api.rohub.org/api/ros/9641a891-0c97-4a21-bcc5-3c0e7f974ede/crate/download/" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede creator mailto:service-account-generation-service assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede dateModified "2025-03-05 00:56:54.503963+00:00" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede datePublished "2021-12-10 10:05:58.607206+00:00" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede encodingFormat "application/ld+json" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede hasPart 863f7285-2401-467b-9d3b-485498dc267d assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede identifier "https://w3id.org/ro-id/9641a891-0c97-4a21-bcc5-3c0e7f974ede" assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede license no-permission assertion.
- 9641a891-0c97-4a21-bcc5-3c0e7f974ede author 0000-0002-2736-0052 assertion.