Matches in Nanopublications for { <http://purl.org/np/RA59XSqRVPk2FrSKMfCxyHV_NVcPGekpLer0BEIbmIb74#association> ?p ?o ?g. }
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- association type Statement assertion.
- association label "While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated." assertion.
- association subject DRUGBANK:DB00904 assertion.
- association predicate treats assertion.
- association object DOID_1574 assertion.
- association has_population_context context assertion.
- association relation OffLabelIndication assertion.
- association publications 29912214 assertion.
- association provided_by NeuroDKG assertion.