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- Meta-analysis%20of%20350%2C504%20individuals%20identified%20147%20loci%20associated%20with%20estimated%20glomerular%20filtration%20rate%20%28eGFR%29%2C%20of%20which%2053%20were%20novel. obtainsSupportFrom s41467-019-09861-z assertion.
- Index%20variants%20in%20the%20identified%20eGFR%20loci%20are%20associated%20with%20related%20traits%2C%20including%20diabetes%2C%20hypertension%2C%20and%20cardiovascular%20disease. obtainsSupportFrom s41467-019-09861-z assertion.
- Seven%20of%20the%2048%20novel%20variants%20and%2027%20of%20the%2085%20lead%20variants%20in%20known%20loci%20were%20at%20least%20nominally%20associated%20with%20one%20or%20more%20kidney-related%20phenotypes%20in%20the%20UK%20Biobank. obtainsSupportFrom s41467-019-09861-z assertion.
- Genetic%20risk%20scores%20constructed%20from%20significantly%20associated%20eGFR%20variants%20explain%209.4%25%20of%20the%20variance%20in%20eGFR%20levels. obtainsSupportFrom s41467-019-09861-z assertion.
- The%20genetic%20risk%20score%20was%20more%20predictive%20of%20chronic%20kidney%20disease%20%28CKD%29%20in%20women%20%28AUC%3A%200.552%29%20than%20in%20men%20%28AUC%3A%200.538%29. obtainsSupportFrom s41467-019-09861-z assertion.
- Sex-stratified%20analysis%20identified%20one%20locus%20with%20significantly%20larger%20effects%20in%20women%20than%20in%20men. obtainsSupportFrom s41467-019-09861-z assertion.
- Sixteen%20genes%27%20expression%20was%20associated%20with%20eGFR%20index%20variants%20specifically%20in%20kidney%20tissues%2C%20including%20five%20genes%20%28APOD%2C%20CDKL5%2C%20DPEP1%2C%20FGF5%2C%20and%20TFDP2%29%20not%20associated%20in%20other%20tissues. obtainsSupportFrom s41467-019-09861-z assertion.
- DEPICT%20analysis%20identified%20482%20significant%20gene%20sets%20enriched%20for%20kidney%20function%20and%20metabolic%20processes%2C%20with%20the%20most%20significant%20being%20related%20to%20kidney%20morphology%20and%20transport%20channels. obtainsSupportFrom s41467-019-09861-z assertion.
- Six%20of%20the%20147%20loci%20showed%20significant%20colocalization%20with%20hypertension%20and%20cardiovascular%20traits. obtainsSupportFrom s41467-019-09861-z assertion.
- One%20locus%20%28prioritized%20gene%3A%20GCKR%29%20showed%20significant%20colocalization%20with%20type%202%20diabetes%20association. obtainsSupportFrom s41467-019-09861-z assertion.
- The%20identified%20loci%2C%20including%20novel%20ones%2C%20explain%207.6%25%20of%20eGFR%20heritability. obtainsSupportFrom s41467-019-09861-z assertion.