Matches in Nanopublications for { ?s ?p <https://doi.org/10.1016/j.bmc.2025.118489> ?g. }
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- Eighteen%20phorbazole%20analogues%20were%20tested%20against%20class%20I%20and%20II%20HDACs%20in%20cell%20lysate%2C%20and%20seven%20showed%20moderate%20activity. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Three%20phorbazole%20analogues%20had%20IC50%20values%20below%2050%20%CE%BCM%20against%20class%20I%20and%20II%20HDACs%20in%20cell%20lysate%20assays. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20initially%20appeared%20to%20reduce%20the%20activity%20of%20HDAC9%20and%20HDAC11%20by%20more%20than%2050%25%20at%2010%20%CE%BCM%20concentration. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20likely%20binds%20HDAC9%20with%20the%20pyrrole%20group%20buried%20in%20the%20active%20site%20and%20forming%20H-bonds%20with%20the%20backbone%20oxygen%20of%20glycine%20residues%20lining%20the%20cavity. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20interfered%20with%20the%20cell%20lysate%20assays%20by%20inhibiting%20luciferase%20in%20a%20dose-dependent%20manner%20with%20an%20IC50%20below%201%20%CE%BCM. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20exhibited%20autofluorescence%20when%20tested%20on%20purified%20HDAC%20proteins%2C%20confounding%20the%20obtained%20results%20during%20both%20the%20pan-HDAC%20screening%20and%20the%20single%20point%20HDAC%20inhibition%20assay. obtainsSupportFrom j.bmc.2025.118489 assertion.
- HDAC%20inhibition%20potential%20of%209%20was%20weaker%20than%20initially%20observed%20when%20measured%20using%20fluorophores%20with%20excitation%20and%20emission%20wavelengths%20outside%20of%20the%20emission%20range%20of%209. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20was%20found%20to%20be%20very%20soluble%20in%20water%20%28418%20%CE%BCM%29. obtainsSupportFrom j.bmc.2025.118489 assertion.
- Compound%209%20demonstrated%20high%20membrane%20permeability%20with%20a%20flux%20of%2048.5%25. obtainsSupportFrom j.bmc.2025.118489 assertion.