Matches in Nanopublications for { ?s ?p ?o <http://purl.org/np/RALdAq2PVpaiqlUT098sFzQK8CwB7RZBMMeDkL-4ypX5A#assertion>. }
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- DB00656 type Drug assertion.
- MONDO_0013600 type Disease assertion.
- context type Cohort assertion.
- association type ChemicalToDiseaseOrPhenotypicFeatureAssociation assertion.
- DB00656 label "Trazodone" assertion.
- MONDO_0013600 label "insomnia (disease)" assertion.
- context label "elderly" assertion.
- association label "Trazodone, the most sedating atypical antidepressant, is widely used as an off-label hypnotic especially in the elderly. Although generally considered safe, it can potentially inhibit midbrain dopaminergic neurotransmission leading to the emergence of extrapyramidal adverse effects. Two previous cases of trazodone-induced parkinsonism have been described after its prolonged use as an antidepressant; however, there is no published case of secondary parkinsonism caused by trazodone in a nondepressed person after its use as a hypnotic. Here, we present a case of rapid development of bradykinetic-rigid parkinsonism temporally linked to the use of trazodone as a hypnotic in a nondepressed elderly man" assertion.
- association subject DB00656 assertion.
- association predicate treats assertion.
- association object MONDO_0013600 assertion.
- association has_population_context context assertion.
- association relation NCIT_C94303 assertion.
- DB00656 category Drug assertion.
- MONDO_0013600 category Disease assertion.
- context category Cohort assertion.
- association category ChemicalToDiseaseOrPhenotypicFeatureAssociation assertion.
- association publications 29634584 assertion.
- association aggregator_knowledge_source knowledge-collaboratory assertion.